Reese Witherspoon

Susan Murphy / Ginormica (voice)

Seth Rogen

B.O.B. (voice)

Hugh Laurie

Dr. Cockroach Ph.D. (voice)

Rainn Wilson

Gallaxhar (voice)

Will Arnett

The Missing Link (voice)

Kiefer Sutherland

General W.R. Monger (voice)

Paul Rudd

Derek Dietl (voice)

Stephen Colbert

President Hathaway (voice)

Julie White

Wendy Murphy (voice)

Jeffrey Tambor

Carl Murphy (voice)

Amy Poehler

Computer (voice)

Ed Helms

News Reporter (voice)

Renée Zellweger

Katie (voice)

Sean Bishop

Private Bullhorn / Helicopter Pilot / Advisor Ortega (voice)

Rich Dietl

Commander / Advisor Smith (voice)