E. G. Daily

Tommy Pickles (voice)

Tara Strong

Dil Pickles (voice)

Cheryl Chase

Angelica Pickles (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Cree Summer

Susie Carmichael (voice)

Kath Soucie

Lil Deville / Phil DeVille / Betty DeVille (voice)

Michael Bell

Drew Pickles / Chas Finster (voice)

Tress MacNeille

Charlotte Pickles (voice)

Joe Alaskey

Grandpa Lou Pickles (voice)

Debbie Reynolds

Lulu Pickles (voice)

Jack Riley

Stu Pickles (voice)

Susan Sarandon

Coco LaBouche (voice)

John Lithgow

Jean-Claude (voice)

Melanie Chartoff

Didi Pickles (voice)

Julia Kato

Kira Watanabe (voice)