Diego Luna

Manolo (voice)

Channing Tatum

Joaquin (voice)

Zoe Saldaña

Maria (voice)

Christina Applegate

Mary Beth (voice)

Eugenio Derbez

Chato (voice)

Cheech Marin

Pancho Rodriguez (voice)

Gabriel Iglesias

Pepe Rodriguez (voice)

Ron Perlman

Xibalba (voice)

Kate del Castillo

La Muerte (voice)

Ana de la Reguera

Carmen Sánchez (voice)

Dan Navarro

Chakal (voice)

Ice Cube

Candle Maker (voice)

Héctor Elizondo

Carlos Sanchez (voice)

Danny Trejo

Skeleton Luis (voice)

Carlos Alazraqui

General Posada / Dali / Chuy (voice)