Diego Luna

Manolo (voice)

Zoe Saldaña

Maria (voice)

Channing Tatum

Joaquin (voice)

Ron Perlman

Xibalba (voice)

Christina Applegate

Mary Beth (voice)

Ice Cube

Candle Maker (voice)

Kate del Castillo

La Muerte (voice)

Héctor Elizondo

Carlos Sanchez (voice)

Danny Trejo

Skeleton Luis (voice)

Carlos Alazraqui

General Posada / Dali / Chuy (voice)

Ana de la Reguera

Skeleton Carmen (voice)

Emil-Bastien Bouffard

Young Manolo (voice)

Elijah Rodriguez

Young Joaquin (voice)

Genesis Ochoa

Young Maria (voice)

Plácido Domingo

Skeleton Jorge (voice)