David Mattey

Toxic Avenger / Noxious Offender

Debbie Rochon

Ms. Weiner

Clyde Lewis

Toxie (voice)

Heidi Sjursen

Sarah / Claire

Ron Jeremy

Mayor Goldberg

Tom Fulp

Painter

Paul Kyrmse

Sgt. Kabukiman / Evil Kabukiman

Stan Lee

Prologue / Epilogue Narrator (voice)

Joe Fleishaker

Chester / Lardass

Dan Snow

Sgt. Kazinski

Michael Budinger

Tito

Lisa Terezakis

Sweetie Honey

Barry Brisco

Pompey

Corey Feldman

Sarah's Gynecologist

Trent Haaga

Tex Diaper