Ian McKellen

Sherlock Holmes

Laura Linney

Mrs. Munro

Milo Parker

Roger

Hiroyuki Sanada

Tamiki Umezaki

Roger Allam

Dr. Barrie

Frances de la Tour

Madame Schirmer

Hattie Morahan

Ann Kelmot

Phil Davis

Inspector Gilbert

Patrick Kennedy

Thomas Kelmot

John Sessions

Mycroft Holmes

Frances Barber

Matinee "Madame Schirmer"

Charles Maddox

Oswald

Takako Akashi

Maya Umezaki

Zak Shukor

Masuo Umezaki

Michael Culkin

Bank Manager