Ryan Reynolds

Wade Wilson / Deadpool / Juggernaut (voice)

Josh Brolin

Cable

Morena Baccarin

Vanessa

Julian Dennison

Firefist

Zazie Beetz

Domino

T.J. Miller

Weasel

Leslie Uggams

Blind Al

Karan Soni

Dopinder

Brianna Hildebrand

Negasonic Teenage Warhead

Jack Kesy

Black Tom

Eddie Marsan

Headmaster

Shioli Kutsuna

Yukio

Stefan Kapičić

Colossus (voice)

Randal Reeder

Buck

Nikolai Witschl

Head Orderly Frye