Roberto Benigni

Roberto (segment "Strange to Meet You")

Steven Wright

Steven (segment "Strange to Meet You")

Joie Lee

Good Twin (segment "Twins")

Cinqué Lee

Evil Twin (segment "Twins") / Kitchen Guy (segment "Jack...")

Steve Buscemi

Danny (segment "Twins")

Iggy Pop

Iggy (segment "Somewhere in California")

Tom Waits

Tom (segment "Somewhere in California")

Joseph Rigano

Joe (segment "Those Things'll Kill Ya")

Vinny Vella

Vinny (segment "Those Things'll Kill Ya")

Vinny Vella, Jr.

Vinny Jr. (segment "Those Things'll Kill Ya")

Renée French

Renée (segment "Renée")

E.J. Rodriguez

Waiter (segment "Renée")

Alex Descas

Alex (segment "No Problem")

Isaach de Bankolé

Isaach (segment "No Problem")

Cate Blanchett

Cate / Shelly (segment "Cousins")