Owen Wilson

Lightning McQueen (voice)

Paul Newman

Doc Hudson (voice)

Bonnie Hunt

Sally Carrera (voice)

Larry the Cable Guy

Mater (voice)

Cheech Marin

Ramone (voice)

Tony Shalhoub

Luigi (voice)

Guido Quaroni

Guido (voice)

Jenifer Lewis

Flo (voice)

Paul Dooley

Sarge (voice)

Michael Wallis

Sheriff (voice)

George Carlin

Fillmore (voice)

Katherine Helmond

Lizzie (voice)

John Ratzenberger

Mack / Hamm Truck / Abominable Snow Plow / P.T. Flea Car (voice)

Joe Ranft

Red / Peterbilt (voice)

Michael Keaton

Chick Hicks (voice)