Daniel Radcliffe

'Weird Al' Yankovic

Evan Rachel Wood

Madonna

Rainn Wilson

Dr. Demento

Toby Huss

Nick Yankovic

Jack Lancaster

Jim

Spencer Treat Clark

Steve

Tommy O'Brien

Bermuda

Arturo Castro

Pablo Escobar

Julianne Nicholson

Mary Yankovic

Diedrich Bader

Grizzled Narrator (voice)

Lin-Manuel Miranda

Doctor

Richard Aaron Anderson

Young Al

Thomas Lennon

Salesman

David Bloom

Teenage Al

Keanush Tafreshi

Kip