Dakota Fanning

Fern Arable

Julia Roberts

Charlotte the Spider (voice)

Steve Buscemi

Templeton the Rat (voice)

John Cleese

Samuel the Sheep (voice)

Oprah Winfrey

Gussy the Goose (voice)

Cedric the Entertainer

Golly the Goose (voice)

Reba McEntire

Betsy the Cow (voice)

Kathy Bates

Bitsy the Cow (voice)

Robert Redford

Ike the Horse (voice)

Thomas Haden Church

Brooks the Crow (voice)

André 3000

Elwyn the Crow (voice)

Dominic Scott Kay

Wilbur (voice)

Sam Shepard

Narrator (voice)

Abraham Benrubi

Uncle the Pig (voice)

Kevin Anderson

Mr. Arable