Whoopi Goldberg

Ranger Margaret (voice)

David Spade

Ranger Frank (voice)

E. G. Daily

Tommy Pickles (voice)

Tara Strong

Dilan "Dil" Pickles (voice)

Christine Cavanaugh

Chuckie Finster (voice)

Kath Soucie

Phil / Lil / Betty DeVille (voices)

Cheryl Chase

Angelica Pickles (voice)

Tim Curry

Rex Pester (voice)

Jack Riley

Stuart 'Stu' Pickles (voice)

Busta Rhymes

Reptar Wagon (voice)

Michael Bell

Charles 'Chaz' Finster Sr. / Grandpa Boris Kropotkin / Drew Pickles (voice)

Joe Alaskey

Grandpa Lou Pickles (voice)

Phil Proctor

Howard DeVille / Igor (voice)

Cree Summer

Susie Carmichael (voice)

Tress MacNeille

Charlotte Pickles (voice)