Alec Baldwin

Theodore Templeton (voice)

James Marsden

Tim Templeton (voice)

Amy Sedaris

Tina Templeton (voice)

Ariana Greenblatt

Tabitha Templeton (voice)

Jeff Goldblum

Dr. Armstrong (voice)

Eva Longoria

Carol Templeton (voice)

James McGrath

Wizzie (voice)

Jimmy Kimmel

Ted Templeton (voice)

Lisa Kudrow

Janice Templeton (voice)

Raphael Alejandro

Nathan / Lead Baby Ninja (voice)

Serenity Reign Brown

Meghan (voice)

David Soren

Jimbo (voice)

Nicholas Gist

The Triplets (voice)

James Ryan

Story Bear (Connie) (voice)

David P. Smith

Movie Patron (voice)