Steve Carell

Gru (voice)

Jason Segel

Vector (voice)

Miranda Cosgrove

Margo (voice)

Dana Gaier

Edith (voice)

Elsie Fisher

Agnes (voice)

Russell Brand

Dr. Nefario (voice)

Julie Andrews

Gru's Mother (voice)

Will Arnett

Mr. Perkins (voice)

Kristen Wiig

Miss Hattie (voice)

Pierre Coffin

Tim / Bob / Mark / Phil / Stuart (voice)

Chris Renaud

Dave (voice)

Jemaine Clement

Jerry (voice)

Jack McBrayer

Carnival Barker / Tourist Dad (voice)

Danny McBride

Fred McDade (voice)

Mindy Kaling

Tourist Mom (voice)