Steve Carell

Gru (voice)

Jason Segel

Vector (voice)

Russell Brand

Dr. Nefario (voice)

Julie Andrews

Gru's Mother (voice)

Will Arnett

Mr. Perkins (voice)

Kristen Wiig

Miss Hattie (voice)

Miranda Cosgrove

Margo (voice)

Dana Gaier Ellis

Edith (voice)

Elsie Fisher

Agnes (voice)

Pierre Coffin

Tim / Bob / Mark / Phil / Stuart (voice)

Chris Renaud

Dave (voice)

Jemaine Clement

Jerry (voice)

Jack McBrayer

Carnival Barker / Tourist Dad (voice)

Danny McBride

Fred McDade (voice)

Mindy Kaling

Tourist Mom (voice)